How does population viral load vary with the evolution of a large HIV epidemic in sub-Saharan Africa?
نویسندگان
چکیده
Using mathematical modelling, we describe the temporal evolution of population HIV-1 viral load in Tanzania throughout the epidemic. Population log10 viral load was found to be stable and not sensitive to epidemic dynamics. However, even modest increases in antiretroviral therapy (ART) coverage were reflected as appreciable reductions in population log10 viral load. As ART coverage expands in sub-Saharan Africa, population log10 viral load will increasingly become a powerful proxy for monitoring ART implementation and HIV incidence trends.
منابع مشابه
Effect of variable transmission rate on the dynamics of HIV in sub-Saharan Africa
BACKGROUND The cause of the high HIV prevalence in sub-Saharan Africa is incompletely understood, with heterosexual penile-vaginal transmission proposed as the main mechanism. Heterosexual HIV transmission has been estimated to have a very low probability; but effects of cofactors that vary in space and time may substantially alter this pattern. METHODS To test the effect of individual variat...
متن کاملComparative population dynamics of HIV-1 subtypes B and C: subtype-specific differences in patterns of epidemic growth.
The human immunodeficiency virus (HIV) pandemic continues to grow at an alarming rate, with a further 5 million new infections in 2003. Some 3.5 million of these were in sub-Saharan Africa, where approximately 70% of the world's HIV-positive population resides. In contrast, the spread of HIV in high-income countries has slowed since its discovery in the 1980s, and in regions such as Western Eur...
متن کاملNon-physician Clinicians in Sub-Saharan Africa and the Evolving Role of Physicians
Responding to critical shortages of physicians, most sub-Saharan countries have scaled up training of nonphysician clinicians (NPCs), resulting in a gradual but decisive shift to NPCs as the cornerstone of healthcare delivery. This development should unfold in parallel with strategic rethinking about the role of physicians and with innovations in physician education and in-service training. In ...
متن کاملNon-physician Clinicians – A Gain for Physicians’ Working in Sub-Saharan Africa; Comment on “Non-physician Clinicians in Sub-Saharan Africa and the Evolving Role of Physicians”
The changing demands on the health sectors in low- and middle-income countries especially sub-Saharan African countries continue to challenge efforts to address critical shortages of the health workforce. Addressing these challenges have led to the evolution of “non-physician clinicians” (NPCs), that assume some physician roles and thus mitigate the continuing shortage of doctors in these count...
متن کاملHIV prevention and treatment research in sub-Saharan Africa: where are the adolescents?
Recurrent panniculitis in a patient receiving protease inhibitor therapy for human immu-nodeficiency virus infection. Some two decades into the, predominantly heterosexual, HIV epidemic in sub-Saharan Africa, we have yet to challenge the epidemic in a concerted fashion in perhaps its most pertinent population. Not only has little intervention research been carried out on adolescents in sub-Saha...
متن کامل